Eat High Fat, Low Carb to Reduce Inflammation

Nutrition is probably the most important modifiable factor for preventing modern diseases. A healthy and anti-inflammatory diet should be rich in saturated and monounsaturated fats, low in vegetal polyunsaturated fats (especially linoleic acid), moderate in animal protein and low in carbohydrates. The main food sources should be fatty animal products. If you want to get the benefits of ketosis (as I do), protein and carbohydrates should be restricted, especially the latter. Beta-hydroxybutyrate is a ketone body, and is a superfuel: it increases the delta G of ATP hydrolysis while reducing oxygen consumption due to its higher inherent energy compared to pyruvate (derived from carbohydrate metabolism.) It also protects against oxidative stress and mitochondrial damage. Ketosis represents an anti-inflammatory metabolic state, increasing mitochondrial respiration, reducing glycolysis, reducing serum levels of mitogenic factors, increasing autophagy, among other effects.