Global Movement and ACL Rehabilitation

By Mark McGrath

In writing a short introduction to the below feedback, I need to be careful to contextualise the role of Convention, while at the same time, informing you of Possibilities beyond this Way of Looking.
If I Injure my Musculo-Skeletal System in a way that compromises my ability to Rehabilitate the injury without surgical intervention, then that is my Logical and Only plausible next step.
Post-Surgery, the Surgeon and other Professionals who deal with Acute rehabilitation protocols are Key to the best possible Healing and Post-Surgery Management.
However, once the Healing process is established, and the Joint is capable of being Loaded, we need to be aware of the Global Body.

The intrinsic posture of the child is undisturbed by the task

The Protocols established by Rehabilitation Professionals will be necessary, but not sufficient for Long -Term ‘Functional Ideal’ over the Years and Decades post major surgery.
This is because the compensatory mechanisms that are an inevitable outcome of any major injury, establish themselves invisibly, as we begin to move and weight-bear in our Rehabilitation.
For example, the Support phase of stepping is a closed chain contraction, that involves the information travelling from the Support Extremity to the Spine, and from the Spine to the Stepping Extremity.  If the CNS detects Insufficiency in this Closed Chain recruitment, it will by-pass the ‘Painful Line’ of Movement, creating a non-preferred Movement Compensation.

Janda Muscle Imbalance Syndromes

In an ACL Reconstruction, this will nearly always be a Frontal Plane ‘Lean Strategy’ on the affected side.  This will remain the ‘Automated Pattern’ until the Brain receives Afferent Information to the contrary.
Professionals, such as myself are interested in how you organise the ‘Central Aspects of Control.’  This is exhibited in your Standing Posture, and the array of Tests that can be done to assess the Nature of your Insufficiency.  This Ability is already an Integrated Way of Looking because the Nature of the Looking is Asking;
  • What aspects of your Functioning are Dominating your Experience, to the Detriment of evenness?
  • What aspects of your Functioning are Absent? (These 2 Observations are inter-related)
  • How do these Dominances/Insufficiencies self-organise as you perform increasingly Complex tasks such as Standing, Squat, Forward fold, Plank Push-Up, Single Leg Stance and Ultimately your Gait Mechanism.
Once this Presentation is Clear, and there is Agreement between Observation and Felt Sense, we can get to work in re-establishing ‘Functional Ideal.’
The below feedback outlines the possibility of what can happen, when we begin to ignore the messaging from the Body, Brain and CNS.  The Feedback is from a Friend and Client who is very sensitive to the changes in her body.
I am sharing the Feedback to Inform about a Post-Conventional Approach, not to diminish the Importance of Convention, Protocols and Progressive Management of Serious Injury.  My goal is to have you consider the Comprehensivity of your Rehabilitation, and to Contemplate the Ramifications through a Life-Span.

From Aposhyan; BodyMind Psychotherapy

Hi Mark
Excuse my few poor words to describe the revelation I have had over the last few weeks but I wanted to share it with you and in doing so, say thank you.
The last few weeks have brought into sharp focus the distinct difference between your approach to finding ideal movement vs current practice.
In my current stage of recovery from my knee reconstruction I had hit the proverbial wall. I was following the “expert” prescribed solution for someone in my position, essentially “get yourself a physiotherapist and join a gym”. Their advice, assessment of my function and treatment has been centred around my affected knee and its condition/appearance relative to my other knee/hamstring.  I was vulnerable enough to assume they knew more than I (could sense within) about my body. It took me two weeks to admit to myself that this approach seemed to be doing more harm than good – my right calf was tight and overworking, my QL was screaming, my left hip was starting to pinch and grab. In general I felt that in loading my right knee, quad & hamstring (to meet their requirements to regain strength) my overall function and ability to move with ease and congruency was actually deteriorating rather than improving.
I had been working with you on those concepts for three years and making significant progress, feeling the best that I have ever been. Yet being vulnerable post injury, I mistakenly thought I had to put that work on hold to listen to those “experts” who could rehabilitate my knee. In doing so I couldn’t see that the reason I wasn’t progressing was because I was getting further away from moving ideally and it was exacerbating old injuries and pain.
I am very glad that I made the decision to see you at that time. It awakened the realisation that seeking ideal is the solution, not only to rehabilitation in the short term but to ensuring I move well in future without long term compensations.
It’s only been a few short weeks since then and I know I’m back on the right path. I feel better inside and out. I have a more global approach to my rehabilitation and I’m back enjoying this ongoing journey of learning that my body (and mind) are capable of more efficient, easier and far better performance and function. Thank you.

IVF, Melatonin and the Falling Redox Potential

A discussion was started recently on an online discussion forum on the topic of miscarriage of an expected IVF baby.  I made the comment that sometimes, when the conditions of existence are not met for the proper creation of a progeny, nature usually sees to it that these efforts do not come to fruition.  I also suggested  that the general cellular states of either mother or father were likely a reason that natural conception was not taking place, and that going into IVF in these states and “forcing the issue” may not be a good idea if the intended result is a healthy baby, epigenetically speaking.  This appeared to have been a rather unpopular statement with some members of the forum, and understandably so, for the urge to reproduce is innate and can be taken as our birthright.  As such many emotions are attached to the subject.  I maintained that it is important to look at the facts with honesty, and stack it against the rising rates of infantile health issues such as autism, infantile hypothyroidism and infantile allergy or food intolerance.

One in six couples in Australia and New Zealand suffer from the burden of infertility.

Infertility is defined as the inability of a couple to achieve conception after a year of unprotected intercourse, or the inability to carry pregnancies through to a live birth.

In the USA, more American women have had medical help to have their babies than ever, according to the recent annual reports from the Society for Assisted Reproductive Technology.  The number of IVF cycles performed each year has increased steadily since 1991, and 2015 is looking as if it may be the year with the highest percentage of babies born through IVF than ever reported previously.

That upward trend is the opposite of American birth rates overall. Since 2007, the American birth rate has been declining steadily.

The question must be asked, what are the changes to our conditions of existence that are resulting in this massive shift in fertility rates in our modern world?  What might be the epigenetic manifestations of a pregnancy resulting from two parents who are sub-optimal at the cellular level in their own health?  We all learn in early school years that two negatives don’t make a positive, yet we let our emotions insist to us that our human condition is somehow immune to this simple math.

It seems appropriate that the first place we should look for problems with fecundity is at the hypothalamic level in the brain, as the master controller, specifically the leptin receptor.  Leptin is the master hormone and scorekeeper for the energy status of every cell in the body.  It is a hormone whos signalling in the brain is critical to the status of all downstream hormones, as well as sperm count and oocyte selection.  Leptin signalling happens to be under the control of correct yoking of the circadian cycles, and melatonin is the middle man.

Melatonin is a hormone secreted by the pineal gland. Exposure to darkness stimulates its release and the presence of melatonin in the system helps to induce the sleep process.

In women who are trying to conceive, melatonin helps to protect eggs from damage, especially during ovulation.

Around midnight when we are approaching peak melatonin secretion, leptin enters the hypothalamus.  It is at this stage that there is a release of prolactin, an incredibly important hormone. A deficiency in prolactin (often found in post-menopausal women) can cause a decline in brain activity, propensity to gain weight, and high levels of inflammatory cytokine molecules associated with lack of recovery and chronic pain. Balanced prolactin levels however increase the recycling of cells, the renewal of cells, and the creation of new cells (autophagy and cellular and mitochondrial biogenesis), and also increases growth hormone release.

Low levels of prolactin = low levels of growth hormone, and this can result in low levels of another very important hormone called DHEA.  Adequate levels of DHEA and growth hormone are what maintains a woman’s reproductive cycle – without adequate levels of these hormones the pattern we see in a woman is that they go into menopause early, or become infertile.  Growth hormone would also seem to be pretty crucial to GROWING a child…

[ted id=957]

One quickly begins to see how an inability of melatonin to enter the suprachiasmatic nucleus, and thus an inability of leptin to enter the hypothalamus can create many downstream issues that have some serious implications for reproduction.

In women who are already pregnant, interference with melatonin levels can also mess with the unborn child. If the fetus does not get the proper amount of melatonin from their mother, their biological clock can also become confused. This has been linked to behavioral problems such as attention deficit hyperactivity disorder (ADHD) or autism in young children.

45-48% of the human brain is wired to light circuits.  These circuits are the critical pathways for circadian signaling of day and night.  The hypothalamus is also in control of accounting for energy by accounting for electrons from food via leptin as discussed earlier. The hypothalamus thus integrates and yokes light and metabolism using this information.  A child may begin life on the wrong clock so to speak, if things are awry in the pathways of the parents.  A circadian mismatch in a mother or father trying to conceive can therefore have devastating effects on energy metastability, and this is most worrying in the maternal system, as the child receives all of its mitochondrial DNA from the mother.

Assuming no exposure to high levels of artificial light from television, movie screens, computer screens, phones, e-readers and bright household light, however, everything should be working just fine.  That might just be a the problem in the modern world.


Trans-generational Epigenetics:

The genome codes for proteins and enzymes. As evolution has progressed, we have added generations of control systems to control these proteins’ behavior, which are based around the ability to move energy into newly evolved systems via selection pressures all dictated by epigenetics. Epigenetic expression is determined ultimately by energy dynamics in cells.

The ability of environmental factors to promote a phenotype or disease state not only in the individual exposed but also in subsequent progeny for multiple generations is termed transgenerational inheritance. The majority of environmental factors such as poor nutrition or toxicants such as endocrine disruptors do not promote genetic mutations or alterations in the DNA sequence. In contrast, these factors have the capacity to alter the epigenome by pre-loading the fetal system with information, most likely via alterations in the redox potential of the carrying mother.

The term redox potential is synonymous with the amount of charge across mitochondrial membranes system-wide, or the total energy potential, and this is signalled to the brain directly via the density of water in the CSF through the collagen/water “power grid” as well as via leptin signalling when circadian cycles are coupled.

The CSF is where our body’s DC current is generated, and it is insulated by its myelin casing, just as an electrical wire is insulated by its plastic coating.  Iodine and ketosis are requirements for myelination of the CNS, and thus the insulation of the DC current, which Becker showed is the electrical force that regenerates all tissues in humans in autophagy during sleep.

Women have less myelin on their brains than men naturally by evolutionary design. Women also suffer more autoimmunity than men for this very reason. Having less myelin makes a woman more sensitive to environmental triggers in order to pass this information onto the next generation. This is the very basis of trans-generational epigenetics itself.

If women lose any significant degree of myelin for any reason, or they lose their DC current for any other reason (poor sleep, fake light/altered melatonin, poor nutrition,) their regenerative capacity gradually diminishes, and they are more apt to develop an autoimmune disease because they can not mount proper signaling in their thymus to properly develop their T Helper cells.

When the DC regenerative current in Schwann cells and the brain’s microglia and oligodendroglia are lost for any reason at all, one can not regenerate the normal arms of neuro immunity or of cellular immunity from your thymus gland where the T Helper cells go to mature.

This means T-Helper-3 cells cannot be activated, so T-Helper-17 cells begin to dominate. When these cells dominate for long enough, calcium leaves the pineal gland and circadian biology is altered further, thus, we lose the yoking of the Vitamin A and D cycle in the brain, and the result is a spike in NF kappa beta and IL- 6 in the brain and peripheral tissues. These are the main inflammatory cytokines in the brain. This causes further leptin resistance and system-wide energy crisis.

The result is that antibodies are made from constantly activated B cells as the T cells can not turn them off and they subsequently “tag” the different tissues subject to this energy loss.

When this happens in the thymus at a certain time of embryologic development, the result can be infantile hashimoto’s disease or celiac disease. If it occurs at after the 8th embryologic week of human development, it will affect the developing hindbrain and dentate nucleus in the cerebellum. This affects the posterior hindbrain, and the result can be autism and its spectrum disorders.

This is how epigenetics can go really wrong when the environment is altered drastically from its natural state to a man made one.

Let’s assume that this has been occurring for a long period of time in a woman who cannot conceive naturally.  The woman may at this stage be depleted of DHEA, and likely adrenal output.  Nature’s rules would deem this an inappropriate cellular situation for fostering new life, as energy status is barely sufficient for mother alone to remain healthy, let alone a tender embryo.  The hormone cascade itself makes this clear, in that when cortisol is called for, it must take substrate (pregnenolone) away from production of progesterone in order for its own production.

IVF gives this mother a chance to dodge natures rules, and fertilise her egg in a lab.  When this embryo is implanted back into the stressed environment of the mother’s uterus what might happen?

The mother with poor adrenal output starts to live off the fetal adrenal system as development continues.  She may also start to “borrow” DHEA from the developing infant, the results of which can eventually be Infantile Adrenal Stress and Exhaustion, childhood immune alterations and intolerances.  It may also set the stage for the transgenerational epigenetic triggering of early onset PCOS and endometriosis as the child develops with a DHEA or pregnenolone-steal pattern in their hormone cascade.  This may also provide an epigenetic trigger for estrogen-based cancers of the epithelium, which seem to be showing up in record numbers in younger women.

IVF is a powerful scientific endeavour that has helped many families achieve what was seemingly unachievable for various reasons such loss of reproductive organs via surgery.  When one is deemed infertile for no known reason, however, it seems sensible to look deeper into the reasons the hormone cascade may be altered.

When our views are from the vantage point of evolutionary biology and energetics, many of medicine’s “modern mysteries” become rather clear cut.  Sometimes in order to move forward we need to look back, and pay honour to the deeper intelligences at play..

Food is Only One Input – Part Two

By Josh Lamaro, Jack Kruse and Yew-Wei Tan

Imagine you were a simple organism born out of this world today, and found yourself in the environment pictured above.  Your task is to become familiar with your surroundings to be able to navigate your way around, and yoke your metabolism for optimal survival in these conditions.
Like being dropped in any new place, the first thing one must do is familiarise themselves with the landmarks and events which will become reliable beacons for reference in spatial navigation.  Brooklyn Bridge.  Big Ben.  The Eiffel Tower.

In a primitive environment, devoid of man made structures, the common reliable feature of every day was, and remains to be, a sinusoidal cycle of light and dark, illustrated beautifully in the above image.
Environmental and circadian signals are sensed by all cells to determine how and when we recycle and maintain the proteins that make up our tissues, determining what life we have, how long we will live it, and how ill or well we will be along the way.

The micropulsations of native and non-native electromagnetic forces control all major biocycles, including the timing of mitotic rhythm and the entire cell cycle.  Any major change in their frequency would be catastrophic for cells.  In fact, experiments already have been done that have shown that vibrational rates near normal and slightly above the Schumann resonance, from 30-100 Hz, cause dramatic changes in the cell cycle timing. This can be extremely deleterious for the management and repair of the protein structures that make up our tissues.


Such protein maintenance and repair is controlled by ubiquination rates, a process chiefly organised by a protein called Ubiquitin.  Ubiquination rates are a critical component of cellular communication and are fundamentally linked to proper SCN function and proper clock controlled cell signaling.  Every cancer on this planet has been linked to defects in ubiquination rates. All ubiquination defects are associated with altered melatonin and sulfated Vitamin D levels, which are fundamentally set and controlled by light, not food.

The concentration of a protein within a cell is determined by the balance between a protein’s degradation and its synthesis.  Studies of protein turnover rates have shown that some proteins are short-lived while others are long-lived.
Long-lived proteins constitute the majority of proteins in the cell. Short-lived proteins are typically key regulatory proteins and abnormal proteins (abnormal proteins are often partially unfolded, and such proteins are prone to degradation).

What might happen when the proteins that are supposed to be long-lived are forced to turnover very quickly?  Or if short lived proteins are left a long time?

Protein turnover is one of the most energy consuming processes to be undertaken by a cell. This means that intricate control of this process is critical for optimal health and energy conservation.

Ubiquitin performs this critical function of controlling protein turnover in a cell by closely regulating the degradation of specific proteins. By regulating protein degradation using cell signalling information, cells can quickly eliminate a protein that in turn regulates another function (like a transcription factor that is needed to express a particular gene). This form of control is very effective, as the elimination of a particular regulatory protein ensures that the process expressed by the regulatory protein is shut-down.
Of course, while Ubiquitin-linked regulation is effective at controlling processes, it is also energetically expensive. If a regulatory protein is needed again, it has to be re-synthesized.

 (An alternative regulatory strategy used by cells is to simply de-activate proteins (by changing their conformation). However, unlike the Ubiquitin-linked regulation, such inactivated proteins can be mistakenly reactivated.)

 Ubiquitin performs it’s duties in an ATP-dependent fashion. This is where Gilbert Ling’s ideas become very important.  Ubiquitin function couples directly to mitochondrial signaling.
Mitochondria are organelles within the cells whereby food is broken down to electrons, and water to protons.  Protons are pumped out at a rapid rate under normal conditions.

Within these protons is stored potential energy, and this potential energy is eventually transferred to water hydration shells surrounding cellular proteins and mitochondria, and existing throughout the entire cell.  This potential energy is stored in the hydronium ion of the exclusion zone of water (EZ).  The EZ is critical to cellular signaling in all life forms. When mitochondria discharge protons, water must be available in close quarters to accept this potential energy package.

If it is not, and mitochondria make too many protons, a positive charge builds up in and around the mitochondria, which lowers the redox potential and creates oxidative damage to the surrounding proteins.

Definition: The redox potential is a measure of the electrical potential across your cell membranes. The bigger the gradient is, or becomes, the more alive and well you remain.
Redox chemistry in and around the cell membranes is the key to precise cell regulation.


Linking Redox Chemistry to Protein Turnover

Gilbert Ling’s research showed that ATP was not the high-energy intermediate that Peter Mitchell’s chemiosmotic theory advocates. Ling instead countered that ATP withdraws electrons from proteins.  When this happens, Ling showed, the thermodynamics and the quantum possibilities of the protein in question are altered.

In essence, the cell is tagging the protein with a new thermodynamic information, so that it’s redox possibilities can either make it exist for long periods of time, or mark it for replacement quickly.

Once the redox tagging is complete, the cellular redox repair machinery will take over using resonant energy transfers from the local electromagnetic oscillations or waves in and around a cell.
This is essentially how a cell evolves in real time to suits its environment.

Why is this important?  Greg Engel showed in plant biophysics experiments that all subatomic particles (electrons and protons) move within living cells as waves or oscillations. When electrons are withdrawn from proteins, it changes their tune, so to speak. This is the manner in which proteins are tagged differently, and is the reason protein turnover is linked intimately to circadian and annual cycles.

Note:  Ubiquitin itself does not degrade proteins. It serves only as a tag that marks proteins for degradation. The degradation itself is carried out by the 26S proteasome. In short, proteins that are to be degraded are first tagged by conjugating them with Ubiquitin and these tagged proteins are then recognized and shuttled to the proteasome for degradation.

What are the Major Protein Degradation Signals?

What determines if a protein gets tagged by Ubiquitin and thus marked for degradation? This question is open for debate, but Ling’s work shows us it is likely the Redox potential of the protein in question.
Redox chemistry is the key to cell regulation and it is subject to proper timing, specifically circadian timing.

Light is an electromagnetic oscillation or wave, and is detected by the SCN in the brain.

If the SCN clock cannot perform time-keeping accurately, then the ubiquination tagging mechanism does not work effectively.  Short-lived partially unfolded proteins may be left longer than desired, hindering cellular actions and resulting in cellular “junk” floating around, or, on the other hand, proteins could be tagged prematurely, leading to energetically-expensive protein turnover.

Almost every disease known to modern medicine is tied to alterations in ubiquination processing.  This is why circadian timing is the most critical aspect of wellness, not the food we eat.  Health and wellness starts with cyclical and structural rhythms, not with food.

One simply needs to try and grow a tomato in the depths of winter to understand that the food itself cannot even exist if the conditions for its existence are not present.

Dr. Luis De LeCea’s work, and the work of many others has shown us that we release our pituitary hormones optogenetically – by cellular communication via light. This means light signalling and timing are fundamentally linked to proper hormone signaling in the human brain.

There is One Food that is Critically Important to this System

There is one nutrient that you need to get from food, and that is the Docosahexanoic (DHA,) found in the marine food chain.  DHA is required to turn these light signals into a usable electrical signal for the brain. This lipid is critical for taking light from the Sun, or from our Gut Bacteria, and then turning that light into an electrical signal that can be captured by our mitochondria.
The human retina has more DHA than does the brain, as it is the interface between external light signals and the brain.  It gives the primary signal to the SCN to run the central pacemaking clock, so that life can manifest properly, and the system can make sense of its environmental pressures, and how to use food electrons.

Blue light is what destroys DHA quickest, and in turn, lowers melatonin, and alters Vitamin D sulfation in the skin and gut.

Serotonin is a neurotransmitter made from dietary breakdown of carbohydrates, particularly foods high in phenylalanine, leucine and tryptophan. These chemicals are found in fruits that grow in long light conditions.  In the gut, serotonin regulates intestinal movements, whilst in the brain it is involved in regulation of mood, appetite and sleep (once converted to melatonin.)
Serotonin balance in the brain is just that…..a balance between light frequency and DHA tissue concentration.  If that relationship is not tightly regulated by ubiquination rates,  the connection to uncouple signaling in the brain gut axis is lost.

Serotonin is synthesized from tryptophan, which is transcriptionally activated by vitamin D3 sulfate.
EPA from marine lipids increases serotonin release from presynaptic neurons, whilst DHA has a massive influence on the serotonin receptor action.

Once the serotonin is absorbed, it is collected in the enterochromaffin cells of the gut. There it is transported in the brain’s vagal and serotonergic nerve tracts. Serotonin is closely regulated in the gut and brain by the presence or absence of light.
It is the absence of light, and reduction of H2 from the gut, that stimulates the production of melatonin from serotonin.  This can only happen when light is absent on our skin, in our eye and from our gut for at least 3-4 hrs.  This is another reason why late night eating is detrimental, particularly starches and sugars.  Eating food at night stimulates such light release from the microbiome.  Just as blue light in the eye blunts melatonin production and destroys sleep, so too does blue light release in the gut.

Circadian mismatches disconnect light entrained circadian cycles from the cell cycle, by uncoupling and disconnecting ubiquination from melatonin.

When we marry a microwaved environment replete in blue light, with the lack of DHA in cell membranes in the eye and SCN, we create the perfect storm.
This combination leads to a complete uncoupling of ubquination from melatonin cycles in the brain and gut.  The interaction of ubiquitin and melatonin is of paramount importance in the activation of the transcription factor NF-κappa Beta. NF-κappa Beta is the emergency system of the cell that ties inflammatory cascades to circadian clock genes.

NF-κappa Beta modulates the global cellular levels of communication, by modulating numerous signal transducing factors such as the tumor suppressor p53.

Blue light frequencies rapidly destroy any remaining DHA in the retina, further slowing the SCN clock in relation to the organ clocks.  We can see here how the advice given by modern Australian ob/gyn practitioners to expecting mothers – to avoid fish consumption – creates an epigenetic disaster for any child born into such a blue light toxic environment. This is one reason metabolic disease is showing up in younger populations in epidemic numbers.

The average modern human looks at their cellphone 150 times a day, delivering a constant toxic dose of blue light to the SCN, destroying melatonin production rapidly.  This is only one source.

Uncoupling fundamental forces of nature uncouples our biologic cycles, and this directly alters how nucleic acids, mitochondria and ubiquination can function.  The more non-native oscillations one faces in one’s chosen environment, the higher the ubiquination rates become, and the more chronic disease one is likely to face.

Eating Wholesome, natural Food is a great start, and absolutely has its benefits.  It is a tool in the toolbox for building optimal health, but it simply isn’t enough to cure a sick body or ensure longevity in a toxic environment.
Pete Evans might tout an “Optimal Paleo Lifestyle,” but clinicians who understand circadian biology know that there are far greater environmental concerns that determine the health outcomes of their patients.

If, like Pete, you believe that altering your diet can fix everything, you may end up investing all of your time and money into doing things that, at best, serve to add only a little energy into your system. What will you do about the 10 different energy-draining stressors that are left unchecked?

This blog presents some science about some of the fundamental forces that govern our health and wellness. These forces go well beyond diet. With a new perspective, we can start re-examining some of the core tenets of our daily practice.

When you know better, you do better.

Food Is Just One Input – Part 1

By Josh Lamaro, Jack Kruse and Yew-Wei Tan

Unavoidable in the Australian media of late has been Pete Evans’ relentless dietary tirade as our “Paleo High Priest”, touting the whole-foods-cure-all-ailments message to the masses (Autism included!)  That’s right, the reason you have autism is because your (or your parents’) diet sucks (!?)
At its heart, the message that Pete Evans and his crew have told the Aussie public is that ‘Paleo’ is about taking a “balanced approach”, returning to eating whole, nutrient-dense foods, and living in a more sustainable and holistic way. The benefits of disease reversal apparently come as an added bonus to those who follow this approach.

Whilst moving towards whole foods and shunning processed junk is undeniably a move in the right direction, what he hasn’t told his fan-base is what happens to mitochondrial signalling when you adopt this lifestyle in the context of a modern world loaded with EMF-transmitting technology.
The human genome has been shaped by millions of years of evolution, during which it adapted to the conditions of existence. These conditions absolutely included the types of food that were available, but were undeniably affected by many other factors.  With so many evolutionary pressures having shaped our genome, and so much having changed in the last 50 years, one has to ask why food became the main target?

Among the many lessons that emerge from the paleolithic record, perhaps the most sobering is that in life, as in the stock market, past performance is no guarantee of future results.

Eating the way we did 10,000 years ago does not guarantee good health in today’s modern world.

Food is a Product of the Environment; Your Environment is not a Product of Food

There is no mention from modern Paleo dogmatists of how food is handled differently in different people, given the drastically varied environments that we each live in.  The dietary differences between the Inuit and the Kitavans confused many Paleo 1.0 subscribers for this very reason.

Pete does not seem to understand the science of how our modern environment negatively affects cellular signalling, and how food is just one of many inputs to a circadian sensing system.

What is “Circadian Signalling”?

Life is 100% about circadian biology and seasonal cycles. It is about the ways in which those cycles determine how food is grown, how it carries energies, and how and where these energies are fed into and used by our mitochondria.

The daily rotation of the Earth on its axis, and the yearly revolution of the Earth around the Sun, require that living organisms adapt to nyctohemeral and seasonal periodicity.
Terrestrial life-forms have developed endogenous molecular circadian clocks to synchronize their behavioral, biological, and metabolic rhythms to environmental cues, with the aim to perform at their best, regardless of these forever changing environmental pressures.  The coordinated circadian regulation of sleep/wake, rest/activity, fasting/feeding, and catabolic/anabolic cycles is crucial for optimal health.

Circadian rhythms in gene expression synchronize biochemical processes and metabolic fluxes with the external environment, allowing the organism to function effectively in response to predictable physiological challenges.

 What does this all mean in english?

It means the goal of the body is simply to match it’s internal signalling mechanisms to respond properly to any external signals. We can say that all systems of the body simply strive for metastability given a changing external environment.  A circadian clock is simply something that measures these external environmental signals, and relays that information to internal components of the system (the body), so that those other components knows what is going on.  These components can then ensure and allow the body to be as energy efficient as possible in its physiological functioning.