The Osteopathy Paradox

By Kuno van der Post

On the one hand osteopaths can hardly claim to treat anyone or anything, but on the other hand millions of people visit osteopaths for anything and everything, and are delighted with the results. And nowhere in osteopathic theory does it say that manipulation cures back pain. What is going on? (Opinion)

Is that an elephant in the room?

Is that an elephant in the room?

1) I’m the first to admit osteopathy can’t cure anything. Yet millions of people consult osteopaths and are extremely happy with the results.

2) There is very little proof that osteopathy can make a difference outside of back pain and a few associated issues. But when osteopaths need help with their own general health, most will ask another osteopath for an opinion before anybody else.

3) The accepted evidence for osteopathy is contradictory or inconclusive, even in everyday matters like back pain. And yet our patients swear by the benefits, and send their friends too.

And the more bizarre, confusing and complex the problem seems to be, the more some people feel let down by conventional medicine, and the more they seem drawn to alternatives such as osteopathy.

Alternative therapy makes more sense to many people, because it seems to match their own world views. In particular, osteopaths do not settle for labelling the patient and consigning them to a lifetime of incurability and drugs: we look for practical, easy, cheap and safe steps to make life better, whatever the problem. And alternatives obey the Hippocratic prime-directive far better than mainstream medicine: that is, to do no harm.

There is no shortage of research into alternative medicine, so why is there so little official acceptance for the benefits?

Do not adjust your reality, there is a fault in research…

When I learned about science, it was not observation that was supposed to validate theory: it was theory that was supposed to explain observation. It no longer seems to be that way.

Until now, the mismatch between research findings and the clinic experience has been blamed on many things, such as deluded practitioners or over-optimistic patients. But at some point we need to turn the spotlight onto research itself and see if that is where the problem lies. Is it really testing what it needs to test, in a way that will find out the truth? Or is it asking all the wrong questions, and relying on false assumptions?

The thing is, osteopaths don’t claim to take a medical diagnosis and then cure it with a prescription, and so it is a mistake to test whether or not we can. For instance, nowhere in osteopathic theory does it say that a consistentlly specified product called manipulation cures a disease called back pain. There have been many rigorous studies asking the question, but absolutely none deconstructing the question itself. If there were, they would reveal the logical holes very quickly. For one thing, back pain is not a disease: it is a symptom with countless possible causes. We keep telling people we don’t treat symptoms, don’t we?

This is why I pay no attention to research into manipulation and back pain, whether the findings are supportive or not. It is like asking if spanners fix engines. I have a box of spanners at home, and I have never seen them fix an engine. That doesn’t mean all engineering is rubbish: but this is the sort of inference many commentators seem entitled to make.

The latest study on neural mobilisation and cervical radiculopathy is really a glorified example of ‘manipulation vs. pain’. No matter that it shows the technique in a positive light, because the whole question is meaningless.

Osteopathic theory starts with a different kind of analysis of the situation, and different outcome intentions. Yes, your symptoms are important, but if the medical paradigm – symptoms: disease: diagnosis: treatment – so often leads nowhere except a worsening of health, then we really should challenge the value of this construct.

What is far more important is why the problem has occured. And the reasons are different for everybody. When the bulk of researchers in our field finally cotton on to this, then they might at last find answers that match the experience of millions of people.

If you want to test what osteopaths do, you need to research what osteopaths do

Forget manipulations and back pain for a minute, and even manipulations and colic. I am far more interested in whether osteopathic principles form a good overall strategy for raising health, and if that is a better route to lasting recovery. Over a century of real world observation suggests they do, and it is. When research begins there, I want to be involved.

It is inconvenient for research that health cannot be measured precisely. We can’t count the people who have avoided illness, or the times we have prevented worsening and complications. When our highest aim is to promote spontaneous natural recovery from within, there is no direct way to measure the difference made by our involvement. I have nothing against measuring outcomes, except that I have no idea how to measure the outcomes osteopathy is concerned with. Too bad: that is the problem researchers have to get over.

Furthermore, trials cannot encompass a patient simply ‘feeling better’ who cannot articulate why, or who gets better in an unexpected way or after a trial is finished. Exceptional recoveries are dismissed as outliers, and complex cases (the sort we are often really good at) don’t qualify for trials because of ‘confounding factors’. Individual case-studies, once the mainstay of medical learning, are now ‘anecdotes’ and not ‘evidence’. And all by some miraculous set of God-given rules, apparently.

For every critic who says osteopaths are resistant to research, there must be hundreds or thousands of people who say things like ‘I no longer need to take my antacids’, or ‘I made it to my grandchild’s wedding’, and who unequivocally credit osteopathy with making a difference.

Patient satisfaction is probably as good a way as any to find out if ‘osteopathy works’. And if something a little more objective is required, we could see how many users live to be 100, or something like that. To be any more precise, there first needs to be a thorough deconstruction of the dogma embedded in research theory.

Positive patient and practitioner experience is largely dismissed as ‘unqualified’, or ‘lacking in objectivity’. Typical justification is circular – there is no evidence this is possible: therefore the practitioner is biased, the patient is probably wrong: therefore we dismiss their testimony etc. Accepting those experiences might require the research community to do some explaining, and so the tail is wagging the dog. Clinicians are expected to alter their own narrative instead, and it isn’t on.

An inappropriate research question is one obvious flaw. On the results side, narrow outcome measures can miss an important effect when it is there. The researcher may be interested in whether a certain intervention will reduce the specified symptom within a month. But I am interested that a general strategy will, via a bespoke intervention, lead to improved overall well-being. In some way. At some point in time. And with no permanent downside. Benefit is benefit.

Take migraine. Stopping a migraine is one thing: I don’t call it much of an accomplishment. Drugs can do it cheaply and easily, while still leaving the patient in a total maze. Stopping the patient from getting migraines every week: that is something else altogether. If we do our job properly, we treat the patient, not the migraine: migraines cease to be a feature in their life, and credit goes to Mother Nature. This isn’t hypothetical: I have seen case after case go like that. Wise patients appreciate that long-term improvement may be incompatible with a quick, direct fix.

The key to all of this is in whether we treat diseases, or whether we treat patients: things we say, but what do they really mean?

We humans heal ourselves. Osteopathy assumes a fundamental acceptance of this, because we would otherwise all be dead. Even doctors promote the idea, I just seldom see clinicians betting their reputations on it. The trick is to remove the obstacles to recovery. We see all the time the staggering ability of the human body to recover once obstacles are addressed, and so that is what the smarter patients are asking for.

[This relates to the osteopatic principle that ‘the body has its own medicine chest’. This does not mean we secrete drugs from some gland: it means that our bodies are self-righting systems, always doing their utmost with the resources available. Health is the default, and symptoms are the manifestations of the body’s drive to maintain health.]

An Alternative Narrative of Health and Disease

In its broadest interpretation, osteopathy says that health is the only real solution to disease. It is a myth that you can make a disease just go away while life goes on unchanged. Once we get comfortable that the only cure comes from within, this is actually very empowering.

Even the idea of diseases – consistently identifiable syndromes with consistent causes and symptoms – may be a myth. It it were true, we ought to know by now the precise cause and cure of every disease. And the medical classification of disease conforms to no consistent rational system. It is totally haphazard in fact. If this paradigm were leading to cures, hospitals ought to be getting smaller, one might think, not bigger. The more we seek health by fighting against things called diseases, the more unhealthy and disease-prone we seem to become.

Our awareness of un-health is usually through healing processes – symptoms – which are generally the body’s healthy reactions to stress and strain. To call this disease is to misrepresent what is going on and then fire missiles at the wrong target.

A Holistic Osteopathy Paradigm

What we find is that two people with exactly the same symptoms can have completely different circumstances: the causes are not the same. And yet two people with similar lifestyles and similar patterns of stress can have completely different health problems.

Medical philosophy emphasises the weakest link in the chain, and makes that the diagnosis. Osteopathic diagnosis and treatment are more to do with the stresses upon or within the system, mechanical stress being number one. But there are many other forms of stress – emotional, nutritional, toxic, occupational, social, to name a few – and they can all create obstacles to healing. Sometimes the most osteopathic thing you can do is to drink a glass of water, or have an early night, because manipulating a tired and dehydrated body achieves absolutely nothing.

And so osteopathic scope of practice is not limited to certain types of disease (as medical specialists are), or to certain parts of the body (like physiotherapy), or to certain techniques (massage therapy). Our scope of practice is determined by the obstacles to recovery, and is as broad as our ability to address them.

Anybody who has ever felt they could sleep for a month after treatment will realise just how much stress can be held in the structure.

Most natural therapy focuses on diet, and rightly so. But complex disease also has structural and postural elements, a fact that modern diet-centred therapies have missed. The need for good mechanical adjustment was already appreciated in natural therapy before Osteopaths took it on. These ideas have very much gone out of fashion, but for mainly political reasons, not because they lack sound reasoning or clinical success.

[Note on osteopathic principles: ‘Structure governs function’, although true, was a later alteration of the much richer ‘Structural integrity, natural immunity’.]

So it is all very well eating the best nutrients possible, but if they aren’t being properly processed and distributed, they won’t solve your problems. Stress is a major disruptor to metabolism: at a fundamental level it alters the balance of circulation, and with it the internal economy of the body.

[Osteopathic principles: The ‘rule of the artery reigns supreme…’ etc. refers to the constantly changing diameter of the blood vessels. Diet is what we eat: nutrition is also about what our bodies do with nutrients. Structural adjustment addresses the processing and internal distribution of resources, by optimising regulation, and limiting unnecessary demands for energy.]

Whether or not the above ideas are currently accepted, they are what shaped Traditional Osteopathy theory and practice. One other vital point of the philosophy is that in a living system, you have to get the whole thing working, and that way all the parts are supported and can take care of themselves. Although we can learn lot from dead machines, they do not behave in this way.

[Osteopathic principles: ‘The body as a unit’ refers to treating the body as a whole, not as lots of parts.]

And hence Traditional or Classical Osteopathy is concerned first and foremost with tuning up the whole person, rather than going straight to the bit that hurts, and then understanding the natural reaction to the changes. And if you want to be safe, it makes sense to set out that way, and not go straight at inflamed tissue, hoping the diagnosis is correct.

A Traditional Osteopathic Method

Our job is not to create change, but to create the conditions for change, and then allow the intelligence of the body to determine what happens next. Osteopathic adjustment is very different from chiropractic manipulation, in a number of ways. The clicks and pops (if they happen) are the product of change not the cause, and so an audible release is not crucial to the result. Many people say osteopathy is gentler and more holistic than chiropractic, and hopefully this explains why. We are not putting bones back in place: we are looking to deal with the reasons they are out of place, and then allow them to adopt a position of better ease. We trust that the body knows what it is doing, and do not try to micromanage it. Acute symptoms are  the body’s cure in action, and so we manage the acute, while treating the underlying chronic background; the opposite of standard practice.

Summary

The difference these ideas make in technique is not something that can be explained in a hurry. Suffice to say not everybody gets their heads around it, even with one-to-one teaching. During osteopaths’ training there is a lot of academic discussion about concepts. But this is largely treated as a matter of historic interest, and it does not translate well into the environment of the modern teaching clinic. The number of teachers able to bridge the gap is very small indeed.

If Traditional Osteopathy is an antidote to anything, it is to high-tech medical healthcare that many feel they have exhausted. It is more concerned with the basic necessities of life than glamorous and heroic intervention. It addresses the bigger picture, because when we do that, the details tend to take care of themselves. It is about supporting the system to find a better equilibrium, rather than controlling everything in sight.

When influential critics (and there are some real busybodies out there) say something ‘works’ or doesn’t, we have to ask what they mean by ‘works’. Drugs don’t ‘work’ either, if what we mean is making sick people healthy by poisoning them.

Every other branch of science now recognises that complex systems behave in non-linear ways. There is no predictable mapping of cause onto effect as we would like, and so we have to find smarter ways of interacting with living things. Controlling all the bits is far too crude an approach. If healthcare is going to talk holism it is time we moved beyond the linear mechanical consciousness of the 20th century.

The pursuit of narrow outcome measures, means that helping the patient now, frequently stacks the odds against them in future, and with complete deniability for us. Most of us are blind to long-term benefit and harm because we are not trained to recognise these broader patterns.

We could say that the research community is to blame for this, by placing published trial data at the top of the totem pole, while arbitrarily downplaying or dismissing all other forms of human knowledge. But I think this feeds off a societal desire for short answers and encapsulated solutions, where complex and original ideas have to fight for survival. In fact it is researchers who have also shown us how badly modern medicine is failing, and who are now igniting the motivation to do things better. That requires better vision. Hopefully the old dinosaurs and their specious buzzwords – best practice (read: standardisation), treatment of choice (prescription) and hierarchies of knowledge etc – will soon move over for something more highly evolved.

If there appears to be any paradox in osteopathy, it is only because of asking the wrong questions; of saying one thing and doing another; of research doctrine putting square pegs into round holes. Patients say they get better, but tests in the lab say it doesn’t work. Well, this is a bit like when physicists proved mathematically that bumblebees can’t fly. Science never fails, but scientists frequently do…

PUFA in Evolutionary and Environmental Context

In life, nothing ever remains the same for very long.  One state is continually moving into another in a ceaseless flow of energy and information.  Change, in this regard, is one of the essential characteristics of life.  Seasonally, we see constant environmental shifts, such as the bright, high energy states of spring and summer, flowing into the darker, lower energy states like winter and autumn.  On a smaller scale, similar shifts are seen on a daily basis between daylight and night time.

Such environmental changes elicit adaptive responses in all organisms, which can be observed seasonally in deciduous plants, for example, who lose their leaves in a process is called abscission.  In some cases leaf loss coincides with winter — namely in temperate or polar climates.  In other parts of the world, including tropical, subtropical, and arid regions, plants lose their leaves during the dry season or other seasons, depending on variations in rainfall.  Abscission demonstrates a conservation of energy when resources for growth or proliferation become scarce.
Many flowerers display reliable rhythmicity during circadian shifts in a 24 hour period, whereby the petals open and proliferate when light is available, and close down when the “stress of darkness” returns:


Similarly, mammals in temperate climates display behaviours of conservation in times of scarcity via the survival mechanisms of hibernation and deep sleep.
Mammalian hibernation consists of torpor phases when metabolism is severely depressed and various metabolically expensive systems and tissues are downregulated in their function.  Hibernation affects the function of the innate and the adaptive immune systems. Torpor drastically reduces numbers of all types of circulating leukocytes. In addition, other changes have been noted, such as lower complement levels, diminished response to LPS, phagocytotic capacity, cytokine production, lymphocyte proliferation, and antibody production.  (This probably underpins the phenomenon of winter illness in humans and the onsets of respiratory tract infections such as common cold around seasonal shifts.)

Stress can be broadly defined as any time in which the energetic requirements of the body outweigh its ability to provide energy.  It is by way of hibernation – of shutting down of expensive apparatus – that survival in times of uncertainty (scarcity stress) is possible for many creatures.

Metabolic Switches

The salmon run is the time when salmon, which have migrated from the ocean, swim to the upper reaches of rivers where they spawn on gravel beds. After spawning, all Pacific salmon and most Atlantic salmon die, and the salmon life cycle starts over again. The annual run can be a major event for grizzly bears, bald eagles and sport fishermen. Most salmon species migrate during the northern hemisphere Autumn (September through November).
Salmon, like all fish, are considered to be cold blooded, as their body temperature varies with their environment.  The unsaturated fat DHA tends to be found in higher concentrations in deep, cold water fish like these, probably suggesting it has roles in maintaining fluidity of membranes and allowing for light capture where it is scarce (Crawford.) Concentrations of DHA are lower in warmer bodied animals – even fish found in the Amazon have more saturated fats than unsaturated.
salmon roe has the highest concentration of DHA of all sources, suggesting the presence of the lipid at the time of spawn – going in to winter – is protective for the eggs in the freezing conditions.

Fatty acid composition of plants also appears to be determined by growth temperature, and chill-resistant plants tend to have a higher composition of unsaturated fatty acids in their membranes.  (note that vegetable or seed oils kept in a refrigerator tend not to harden, wheras saturated fat such as the tropical coconut oil tend to harden at room temperature.)

The effects of the consumption of unsaturated fats on warm blooded mammals also has the effect of coupling the organism to its local environment, whereby the ingestion of food acts like information for the system.  In this regard, the environmental lipids ingested by the animal may help in slowing the metabolism to prepare for hibernation.
It is well established that unsaturated fats suppress the metabolic rate, apparently creating hypothyroidism. Lab animals fed a PUFA deficient diet, (Burr and Beber 1934), displayed markedly higher metabolic rates compared with those who consumed PUFA.
PUFA deficiency is associated with increased activity of cytochrome oxidase – a fundamental mitochondrial respiratory enzyme (Kunkel and Williams 1951).  The more unsaturated the oils are, the more specifically they seem to suppress tissue response to thyroid hormone, and transport of the hormone on the thyroid transport protein.

Again we see a coupling of natures energy flows when we take a 50,000 foot view, that metabolism should increase when substrate is available and abundant (spring/summer,) when fatty acids are more saturated, and a suppression of metabolism when substrate is scarce (fall/winter) and PUFA rises.  PUFA really do, in thise sense, appear to be a metablic switch to “survival metabolism.”  A higher metabolic rate in the face of low substrate availability (scarcity) would be disastrous for any organism as it would entail literally oxidising any resources possible – effectively metabolising oneself to death.

Lifespan Considerations

The Fountain of Youth is a spring that supposedly restores the youth of anyone who drinks or bathes in its waters. Tales of such a fountain have been recounted across the world for thousands of years, appearing in writings by Herodotus (5th century BCE), the Alexander romance (3rd century CE), and the stories of Prester John (early Crusades, 11th/12th centuries CE). Stories of similar waters were also evidently prominent among the indigenous peoples of the Caribbean during the Age of Exploration (early 16th century), who spoke of the restorative powers of the water in the mythical land of Bimini.
The legend became particularly prominent in the 16th century, and ambiguity of the concept still continues to be an obsession amongst modern day humans.  There seems to be an innate attachment youthfulness as one ages.  Perhaps it is the longing for the energy of youth that one seems to only see the value in once it is gone.
The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues.  Whatever the case, humans seem hellbent on finding the “sountain of youth” in pill form, or something they can purchase.

The “rate of living” hypothesis is popular amongst anti aging practitioners, some of whom subscribe to the notion that you can live fast and die young, or live slow and last a lot longer.  The rate of living theory postulates that the faster an organism’s metabolism, the shorter its lifespan. The theory was originally created by Max Rubner in 1908 after his observation that larger animals outlived smaller ones, and that the larger animals had slower metabolisms.
This theory has been clearly refuted by metabolic studies that are showing the opposite can be true – that intensified mitochondrial respiration decreases cellular damage, and supports a longer life-span. For example, small dogs eat much more food in proportion to their size than big dogs do, and small dogs have a much greater life expectancy than big dogs, in some cases about twice as long (Speakman, 2003). A similar association of metabolic intensity and life-span is seen in organisms as different from one another as are bacteria and mammals.

Bats, Birds and Tortoises all have extremely long lifespans when adjusted for body mass.  Bats and birds display an incredibly high metabolic rate, whilst tortoises have some of the lowest metabolic rates.  Tortoises are simple organisms, who, literally and figuratively, lead a sheltered life, moving around slowly and seemingly not being exposed to many stressors.
Conversely, birds and bats with their incredibly high metabolic rate, have the constant need for food, entailing moving about the environment and exposing themselves to stressors such as predators, environmental toxins, as well as constant energy expenditure in doing so.  It seems to handle a barrage of stressors, one requires energy.

In all of nature, it appears that higher energy states favour complexity, and lower energy states favour simplicity of organisms, pointing to the brilliance of Lamarck’s theory of evolution.

In a clinical sense, the rate of living theory is oversimplified.  Cell turnover needs to be qualified according to the context. Trying to keep ubiquitination and apoptosis low is not a winning strategy for many cells, and the conditions for the cells that should not turnover, like cardiac and brain tissue, require a high metabolism (brain tissue metabolism can be definition never be low, and even in prolonged fasting, there are huge adaptations to maintain the high energy state of the brain.)
On the other hand, if skin cells and intestinal cells are not turning over every 1-3 days, you are in for big trouble. Even peripheral nervous system tissue is probably something that we want to be able to turnover at appropriate intervals. This applies to everything from wound healing to movement quality to gut functions (the gut is heavily innervated, and needs to modify those networks accordingly). The collagen matrix and connective tissues that give the body its structure (and function!) need to be re-built on a daily basis, lest major degradation in movement occurs. Even the liver needs to turnover all it’s cells every few months.

We can then see how clinically, an attachment to the rate of living theory (or an inability to see things from a broader, energetic perspective) may explain the reason why things like omega 3 oils are routinely prescribed for inflammatory conditions. Often, patients seem to have good (short term) results (due to immune suppression,) but might this strategy be creating down-regulation of other systems to a “hibernation state” whilst the organism is still stuck in the crossfire of modern life stress?
Having high PUFA in blood and tissue is a great way to become insulin resistant, suppress hormone production, suppress immune function, slow down cell turnover, and drastically reduce metabolic rate and nutrient needs (just to name a few effects). This is a survival advantage for the many animals who rely on such adaptations to go through hibernating periods.  The same mechanics applied (though to a lesser degree) to humans in pre-electric times to help them get through low light environments.  It could certainly be used to slow down a body that is spiralling out of control, but should these things be implemented as an anti-aging strategy, as is so often touted?  A recent course i attended gave a “basic anti aging program” for an otherwise healthy adult, that included 6-8g of fish oil a day!

With PUFA depletion, hormone production and sensitivity of all forms increases, cell turnover increases, nutrient needs increase, and adaptability to various stressors increases.
Guenter Albretch-Bueller’s cell intelligence and ‘Anarchy of the Genome’ works show that metabolism is what cells use to generate the light signals they use to communicate with each other.  This means high metabolism is the “adaptive state” whereby groups of cells relay local and global environmental information to each other, and select (and modify) the genes needed to deal with that environment.

 

Idealabs now at Paleo Osteo

Idealabs is a small American company producing high quality boutique supplements with the focus of supporting a healthy metabolism.

Paleo Osteo are now an Australian stockist for Idealabs, and offer the following products from the Idealabs range:

 

ESTROBAN: Estrogen support and control*

estroban_small Topical high purity fat soluble vitamins K (MK-4, menatetrenone), vitamin E (mixed tocopherols, high gamma), vitamin A (as palmitate and/or acetate), and vitamin D.
The fat soluble vitamins have many roles in the body, but most notably they tend to antagonize and block the harmful effects of excessive Estrogen in the body.
Excessive estrogen or estrogen dominance is associated with the following symptoms and pathologies:

  • Acceleration of the aging process
  • Allergies, including asthma, hives, rashes, sinus congestion
  • Autoimmune disorders such as lupus erythematosis, thyroiditis,and Sjoegren’s
  • Breast cancer
  • Breast tenderness
  • Cervical dysplasia
  • Cold hands and feet as a symptom of thyroid dysfunction
  • Copper excess
  • Decreased sex drive
  • Depression with anxiety or agitation
  • Dry eyes
  • Early onset of menstruation
  • Endometrial (uterine) cancer
  • Fat gain, especially around the abdomen, hips and thighs
  • Fatigue
  • Fibrocystic breasts
  • Foggy thinking
  • Gallbladder disease
  • Hair Loss
  • Headaches
  • Hypoglycemia
  • Increased blood clotting (increasing risk of strokes)
  • Infertility
  • Irregular menstrual periods
  • Irritability
  • Insomnia
  • Magnesium deficiency
  • Memory loss
  • Mood swings
  • Osteoporosis
  • Polycystic ovaries
  • Premenopausal bone loss
  • PMS
  • Sluggish metabolism
  • Thyroid dysfunction mimicking hypothyroidism
  • Uterine cancer
  • Uterine fibroids
  • Water retention & bloating
  • Zinc deficiency

In addition, vitamin A is a fundamental precursor for the conversion of LDL cholesterol to the sex steroids and the corticosteroids, and the importance of vitamin D in the body cannot be overstated.
The bone benefits of vitamin K2 are known to many people on the forum, some of its “niche” effects are not widely known.  These include control of inflammation, beneficial effects in heart disease, diabetes, kidney health and cancer, as well as fostering optimal neurological health.

Serving size: 8 drops
Servings per bottle: about 30

 

STRESSNON: Putting the Brakes on Stress*

stressnon_smallTopical Pregnenolone 10mg w DMSO in a 20% Ethanol Solution.

Pregnenolone is the “master hormone” or the first hormone produced from the conversion of LDL cholesterol via active thyroid hormone (T3) and vitamin A.  It serves as the precursor to every other sex hormone and corticosteroid in the pathway.

In times of stress pregnenolone becomes diminished as it flows through the progesterone pathway to make the vital stress hormone cortisol.  These stress hormones shift metabolism away from thryoid driven metabolism to the stress or shock metabolism, and can eventually destroy the thyroid itself.  Underactive thyroid = no ability to make pregnenolone
Should pregnenolone become inadequate but stressors remain, the body shifts towars further stress state.

StressNon is of benefit to those with sluggish thyroid production, or those under high stress (basically everyone!)

 

SOLBAN: Skin Health and Sun Block*

solban_smallSolBan is a product for people interested in improving skin health or for management of issues like hair loss, wrinkles, aging spots, cellulite, or simply protection from the sun.

SolBan is a liquid mixture of niacinamide, caffeine, and aspirin. These ingredients have been shown in multiple human clinical trials (as well as animal studies) to have a highly protective effect on the skin against a number of harmful agents and processes.
The list of harmful agents and processes includes sunlight (UV), metabolic disturbances, aging (wrinkles, cellulite), hormonal imbalance (acne, eczema, melasma), stress, polyunsaturated fats (PUFA), etc.
SolBan is a 20 % alcohol (ethanol) solution in a 2oz glass spray bottle. The product is intended for external use only.

Each bottle contains the following ingredients:
Niacinamide / Nicotinamide – 4% concentration (by volume)
Caffeine – 1% concentration (by volume)
Aspirin – 1% concentration (by volume)

The recommended method of administration is spraying the affected skin area until it has a thin layer of the solution and the letting it dry (without rubbing). The product can be used in place of a sunscreen solution (http://www.ncbi.nlm.nih.gov/pubmed/16864596) due to the UV-blocking properties of caffeine and niacinamide / nicotinamide

some references for the effects of these ingredients on skin health: here


TYROMAX: Pure Natural Dessicated Thyroid*
tyromax_smallTyroMax is a liquid dietary supplement containing natural dessicated thyroid (NDT) of porcine and bovine origin. NDT contains roughly 75% T4 and 25% T3 so is great for people currently taking thyroxine but not feeling better.
It is USP quality, which means it is certified as suitable for human consumption. This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.

Natural dessicated thyroid (NDT), USP, 3X Strength – 1 grain ***Note that this is a 3x potency product, meaning 1/3 grain of Tyromax has equivalent strength of 1grain of other NDT products.

Servings per container: about 30 (90 if 1/3 dose, see below)
Serving size: 24 drops (for equivalent 3 grain strength) 8 drops for equivalent 1 grain
Each serving contains the following ingredients:

Other ingredients: DMSO, glycerin (veg), ethanol.

OXIDAL: Mitochondrial Health and Oxidation*
oxidal_smallOxidal is a liquid supplement that supports optimal oxygenation of tissues and cells. Each of the ingredients in Oxidal has been shown increase cellular oxygen consumption, uncouple oxidative metabolism, and thus support more optimal cellular health.
Methylene Blue can act as an alternate electron transport carrier in the place of oxygen to carry electrons through to complex 4 of mitochondrial electron transport, producing ATP in the absense of oxygen.  It also displays similar benefits to LLLT in displacing Nitric Oxide from complex 4, which would generally hinder electron transport and oxidative metabolism.  In this way methylene blue has been shown to be extremely neuroprotective as it fosters ATP production in the brain.
Oxidal can be applied to the skin, or taken orally in water or juice

Protective role of methylene blue in Alzheimer’s disease
http://www.ncbi.nlm.nih.gov/pubmed/20463399

Serving size: 1 drop
Servings per container: about 240
Each drop contains the following ingredients:
Methylene Blue (MB), USP: 0.4mg (400mcg)
Caffeine, USP: 0.4mg (400mcg)
Benzoic acid, USP: 0.04mg (40mcg)

Other ingredients: ethanol (20%), distilled water

 

LAPODIN: Premiere Quinones for Health*

lapodin_smallLapodin is a dietary supplement containing the napththoquinone beta-lapachone (β-lapachone) and the anthraquinone emodin. The name is a combination of the names beta-lapapachone and emodin. Both quinones have been the subject of hundreds of independent studies going back to the early 1900s, and are purported to have a powerful systemic effect on health, including boosting metabolism/respiration.
Both emodin and beta-lapachone are intimately involved in the proper functioning of the electron transport chain, the recycling of NADH back to NAD – protecting from the systemic effects of stress and aging. In addition to these metabolic / systemic effects, both quinones have been shown to have a staggering array of effects including protecting from radiation, hypoxia, inflammation, endotoxin, diabetes, cortisol, aldosterone, estrogen, prolactin, serotonin, histamine, nitric oxide (NO), carbon monoxide (CO) viruses, bacteria, fungi, and even the aging process in general.

This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.

Servings per container: about 30
Serving size: 24 drops
Each serving contains the following ingredients:

Beta-lapachone / β-lapachone (from bark extract) – 40mg
Emodin (from bark extract) – 80mg

Other ingredients: DMSO, ethanol

For a list of journal articles on the benefits of Lapodin, click here

 

PROGESTENE: Anti-Aging and Metabolism*

progestene_smallProgestene is a liquid dietary supplement providing highly bioavailable and bioidentical, high-purity progesterone (USP grade). The multiple benefits of progesterone have been extensively researched over the last century by leading scientists including Dr. Ray Peat. Some of the better known effects of progesterone include estrogen control, oxidative metabolism support, brain health and memory support, skin health support, eye health support, breast / uterine / ovarian health support, thyroid support, etc. Studies show that progesterone (just like pregnenolone and DHEA) levels steeply decline during aging and drop by over 90% in menopausal women, and by over 60% in men over 60. As such, it is considered as one of the steroids of youth and a number of benefits have been attributed to restoring it to youthful levels.

In addition Progestene will aid in the correction of the dysfunctions associated with estrogen dominance as outlined in the ESTROBAN description, as well as here

Servings per container: about 30
Each serving (24 drops) contains the following ingredients:
Progesterone, USP – 20mg

Other ingredients: DMSO, 20% ethanol
The product is intended and sanctioned for external use only.

The recommended method of administration is using the built-in dropper to place several drops on a body part (preferably without hair) and then rub it in gently. Studies show that healthy, young women produce 15mg – 20mg progesterone daily. As such, this is the suggested daily dose of Progestene. Since progesterone can be highly sedative (especially in males) it is recommended that Progestene be taken in several smaller split doses throughout the day. In addition, please take into consideration its sedative effects before driving or operating machinery.

Some references for the beneficial effecs of progesterone here and here

 

ENERGIN: Energy and Neurotransmitter Support*

Screen Shot 2016-02-25 at 10.50.05 AMThis supplement is a mix of high purity B vitamins in 20% ethanol.
Other than the B vitamins (all of them with greater than 99.9% purity) and the diluted ethanol, there is nothing else in the bottle. Here are some basic facts about the supplement.

Bottle size – 2oz (~60g)
Servings per container – 30
Serving size – 2ml (~2g)

Each serving contains:

Thiamine HCL (Vit. B1): 50 mg
Riboflavin 5′ Phosphate (Vit. B2): 20 mg
Niacinamide (Vit. B3): 100 mg
Pyrodoxine 5′ Phosphate (Vit. B6): 6 mg

The topical absorption is over 90% for the vitamins above, making it an ideal replacement for vitamin B injections.

 

MELANON: For Skin Spots, Moles, Blemishes

Screen Shot 2016-02-25 at 11.01.45 AMMelaNon is dietary supplement for skin health. It contains the citrus flavonoid naringenin as well as the flavone apigenin most commonly found in chamomile. MelaNon also contains caffeine for improved estrogen control and skin health. All of the ingredients have been extensively studies for health purposes, but most of the research on naringenin / apigenin focuses on their anti-neoplastic effects, and especially their effects on skin formations such as moles of various types. This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.

Servings per container: about 30
Serving size: 8 drops
Each serving (8 drops) contains the following ingredients:

Caffeine – 3mg
Apigenin – 3mg
Naringenin – 3mg

Other ingredients: DMSO, ethanol.

References for the various benefits of MelaNon found here

 

 

 

 

The Mirena and Menstrual Woes

The MirenaMIRENA IUD istockA client recently asked if i would write a piece on the Mirena contraceptive device, and i think it is well overdue with all the clinical disasters i have seen occur as a result of its prescription over the years.

For those unaware, the Mirena is an Intra-uterine contraceptive device that secretes a synthetic progesterone surrogate known as Levonorgestrel. The two most common uses of the Mirena are for hormonal contraception, and to prevent endometrial hyperplasia (overgrowth) from unopposed estrogen in functional oestrogen dominance or hormone replacement therapy. The Mirena device is also used to “treat” secondary amenorrhea, dysfunctional uterine bleeding and endometriosis, and as palliative treatment of endometrial cancer.

The synthetic progesterone from the Mirena essentially “tricks” the body into thinking it is pregnant through constant secretion. Progesterone’s normal effects include a role in the maintenance of pregnancy, which requires the prevention of additional pregnancies during the course of an established one – herein lies the use of progesterone in birth control.

The Normally Functioning Menstrual Cycle

Menstrual Cycle

The menstrual cycle is regulated by the complex interaction of a few key hormones: luteinizing hormone, follicle-stimulating hormone, and the female sex hormones estrogen and progesterone .

The menstrual cycle begins with menstrual bleeding (menstruation), which marks the first day of the follicular phase. Bleeding occurs after estrogen and progesterone levels decrease at the end of the previous cycle.
This decrease causes the top layers of thickened lining of the uterus (endometrium) to break down and be shed. About this time, the follicle-stimulating hormone level increases slightly, stimulating the development of several follicles in the ovaries.
Each follicle contains an egg. Later, as the follicle-stimulating hormone level decreases, only one follicle continues to develop. This follicle produces estrogen .

The ovulatory phase begins with a surge in luteinizing hormone and follicle-stimulating hormone levels. Luteinizing hormone stimulates egg release (ovulation), which usually occurs 16 to 32 hours after the surge begins. The estrogen level peaks during the surge, and the progesterone level starts to increase.

During the luteal phase, luteinizing hormone and follicle-stimulating hormone levels decrease. The ruptured follicle closes after releasing the egg and forms a corpus luteum, which produces progesterone .
During most of this phase, the estrogen level is high, but progesterone should outnumber its presence by a 300-400:1 ratio in a fully fertile healthy woman.
Progesterone and estrogen cause the lining of the uterus to thicken more, to prepare for possible fertilization. If the egg is not fertilized, the corpus luteum degenerates and no longer produces progesterone, the estrogen and progesterone levels decrease, the top layers of the lining break down and are shed, and menstrual bleeding occurs (the start of a new menstrual cycle).
If the egg IS fertilized, progesterone remains high, as its anti-inflammatory and protective properties (described below) ensure optimal health of mother and child.

Hormone and Menstrual Irregularity, a leading sign of stress

Below is a simplified diagram of the hormone cascade, outlining the synthesis of hormones (pregnenolone) from LDL cholesterol, using the cofactors Free T3 and Vitamin A, through to the end products of the steroid hormones.

Inflammation CholesterolThe human hormone cascade really does show the genius of nature at work in the way it is set up. The body is geared to read and react to environmental pressures, and survive at all costs in the face of stress. We can survive without Progesterone, but not without the life saving stress hormone cortisol.

Cortisol is the “wonder drug” that allows a human being to jump onto a roof out of the way of a derailed train, and leaves them wondering how in the hell they got there. It is what allows someone to lift a car off a crushed pedestrian after an accident. But our stress responses are geared for acute stressor like these only. The problem in a modern world is that the stressors we face are both chronic and numerous.

Note that a precursor for Cortisol is Progesterone. In essence, cortisol takes precedence at the expense of the sex hormones, for there is no point putting energy into the creation of a progeny when survival is at stake! The body is geared to only produce offspring when the conditions of existence are favourable, and stress is low, to ensure optimal health for both mother and child, and best epigenetic outcomes. Many issues involving bleeding irregularity, heavy periods, endometriosis (in fact everything that the mirena is used to treat) could be seen as a direct result of stress to the system, and the consequent shunt of progesterone to cortisol, resulting in estrogen dominance.

Summary: increased cortisol = decreased progesterone = low Progesterone:Estrogen Ratio = Crazy Fucked up Menstrual Symptoms.

SO….what does the Doctor do?

PrEsCriBe MiReNa oF CoUrsE – BcOz ProGeSterOne RiTe??

Wrong.

Naming and Confusion with Progesterone-Like Substances – The Problem with Progestins

All synthetic progesterones fall under the broad category PROGESTINS. Although Progestins act by binding to the Natural Progesterone “receptor,” and impart some similar actions in terms of signalling as natural progesterone does, it should be noted that they do not produce ALL the beneficial effects of true endogenous progesterone, and often act in opposition to natural progesterone in many ways, namely by competing with it at the cell “receptor” site, and affecting its endogenous production through negative feedback.
In fact, the in vitro relative binding affinities of Levonorgestrel at human steroid hormone receptors is 323% that of natural progesterone, meaning it is a direct competitive inhibitor of natural progesterone.

Levonorgestrel in the Mirena IUD is considered a progestin because it modifies the uterus in approximately the way progesterone does (by thickening the uterine and cervical lining,) but it is also luteolytic, and lowers the ovaries’ production of endogenous progesterone. Levonorgestrel s not supportive of gestation in the way that natural progesterone is (it has been used historically as the major active ingredient in the “morning after pill”), which should point to the reasons for concern in its liberal use – it lacks the beneficial anti-inflammatory, pro-gestational, restorative properties of natural Progesterone.

Severe “side” effects of Mirena (effects):
• severe cramps or pelvic pain;
• extreme dizziness, feeling like you might pass out;
• heavy or ongoing vaginal bleeding, vaginal sores, vaginal discharge that is watery, foul-smelling, or otherwise unusual;
• severe pain in your side or lower stomach;
• pale skin, weakness, easy bruising or bleeding;
• fever, chills, or other signs of infection;
• pain during sexual intercourse;
• sudden numbness or weakness, especially on one side of the body;
• sudden or severe headache, confusion, problems with vision, sensitivity to light;
• jaundice (yellowing of the skin or eyes); or
• signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious “side” effects may include:
• irregular menstrual periods, changes in bleeding patterns or flow;
• breakthrough bleeding, or heavier menstrual bleeding during the first few weeks after device insertion;
• back pain;
• headache, nervousness, mild dizziness;
• nausea, vomiting, bloating;
• breast tenderness or pain;
• weight gain, acne, changes in hair growth;
• depression, anxiety, mood changes, loss of interest in sex;
• mild itching, skin rash; or
• puffiness in your face, hands, ankles, or feet.
This is not a complete list of side effects and others may occur.

Progestins vs Progesterone

In contrast to Levonorgestrel, endogenously produced natural progesterone has a positive effect on the corpus luteum, further stimulating progesterone synthesis, and supporting gestation.
Progesterone participates in practically every physiological process in both men and women. Its tremendous increase during pregnancy serves to stabilize the organisms, both mother and child, during that crucial time. The stabilizing action of progesterone is especially visible in muscle tissue, such as the uterus, blood vessel walls, the heart, the intestines and the bladder. Less visibly, progesterone stabilizes and normalizes nervous, secretory and growth processes.
At levels reached just before delivery, progesterone produces anesthesia and contributes to tissue elasticity in the mother, allowing for easy delivery.  The rates of caesarian section deliveries in a modern world point toward estrogen dominance/progesterone deficiency.

The growing fetus requires large amounts of glucose, and progesterone makes it possible to be provided in abundance for ideal brain growth, by promoting the mother’s ability to use fat for her own energy. It is this efficient use of fat which gives women greater long-range endurance than men. When progesterone is deficient, there tends to be hypoglycemia, often combined with obesity.  Conversely when Progesterone is abundant, women tend to really “find their groove” in terms of body composition.  This is likely also an evolutionary signal to the opposite sex that the female is in good shape to have a healthy baby.

Recent studies show that progesterone prevents stress-induced coronary blood vessel spasms in aged hearts – probably explaining women’s relative freedom from heart attacks, so long as they retain functioning ovaries.  Other studies suggest that progesterone has a role in regeneration of damaged brain cells and prolonged growth of the brain. Delayed aging and longer life span have been very clearly related to extra progesterone.

Since progesterone normalizes the immune system (it causes thymus regeneration, for example) it is very effective in autoimmune diseases (which result from adverse reactions to one’s own tissues) and in those degenerative disease which have an autoimmune component.

Progesterone has been found experimentally to be the basic hormone of adaptation and of resistance to stress. The adrenal glands use it to produce their anti-stress hormones, as outlined above, and when there is enough progesterone, they don’t have to produce the potentially harmful cortisol. In a progesterone deficiency, we produce too much cortisol, and excessive cortisol causes osteoporosis, aging of the skin, damage to brain cells, and the accumulation of fat, especially on the back and abdomen.
Progesterone also relieves anxiety, improves memory, protects brain cells, and even prevents epileptic seizures. It reverses many of the signs of aging in the skin, and promotes healthy bone growth. It can relieve many types of arthritis, and helps a variety of immunological problems.

SUMMARY: Progestins =/= Progesterone, Levonorgestrel is NOT Progesterone.

Levonorgestrel imparts an Estrogenic effect, despite mimicking some of the functions of Progesterone, by competing heavily for the Progesterone Receptor, and lowering normal progesterone production – sometimes irreversibly.

Lower endogenous Progesterone is linked with early onset of diseases of aging including osteoporosis, wrinkling skin, cognitive decline, obesity, arthritis and heart disease.