Benefits of Progesterone (Progestene)

Progesterone participates in practically every physiological process in both men and women. Its tremendous increase during pregnancy serves to stabilize the organisms, both mother and child, during that crucial time. The stabilizing action of progesterone is especially visible in muscle tissue, such as the uterus, blood vessel walls, the heart, the intestines and the bladder. Less visibly, progesterone stabilizes and normalizes nervous, secretory and growth processes.
At levels reached just before delivery, progesterone produces anesthesia and contributes to tissue elasticity in the mother, allowing for easy delivery.  The rates of caesarian section deliveries in a modern world point toward estrogen dominance/progesterone deficiency.

The growing fetus requires large amounts of glucose, and progesterone makes it possible to be provided in abundance for ideal brain growth, by promoting the mother’s ability to use fat for her own energy. It is this efficient use of fat which gives women greater long-range endurance than men. When progesterone is deficient, there tends to be hypoglycemia, often combined with obesity.  Conversely when Progesterone is abundant, women tend to really “find their groove” in terms of body composition.  This is likely also an evolutionary signal to the opposite sex that the female is in good shape to have a healthy baby.

Recent studies show that progesterone prevents stress-induced coronary blood vessel spasms in aged hearts – probably explaining women’s relative freedom from heart attacks, so long as they retain functioning ovaries.  Other studies suggest that progesterone has a role in regeneration of damaged brain cells and prolonged growth of the brain. Delayed aging and longer life span have been very clearly related to extra progesterone.

Since progesterone normalizes the immune system (it causes thymus regeneration, for example) it is very effective in autoimmune diseases (which result from adverse reactions to one’s own tissues) and in those degenerative disease which have an autoimmune component.

Progesterone has been found experimentally to be the basic hormone of adaptation and of resistance to stress. The adrenal glands use it to produce their anti-stress hormones, as outlined above, and when there is enough progesterone, they don’t have to produce the potentially harmful cortisol. In a progesterone deficiency, we produce too much cortisol, and excessive cortisol causes osteoporosis, aging of the skin, damage to brain cells, and the accumulation of fat, especially on the back and abdomen.
Progesterone also relieves anxiety, improves memory, protects brain cells, and even prevents epileptic seizures. It reverses many of the signs of aging in the skin, and promotes healthy bone growth. It can relieve many types of arthritis, and helps a variety of immunological problems.

other-hormones-the-role-of-estrogen-and-progesterone-infographic

http://www.ncbi.nlm.nih.gov/pubmed/25196424“…Despite these low serum levels, salivary and capillary blood levels are very high and a protective endometrium has been reported in a limited number of studies. Topical alcohol-based, but not water-based, gels appear to yield luteal-phase serum progesterone levels but studies with these preparations are scant. Long-term studies with percutaneous progesterone creams and gels are likely to provide valuable information for treatment of postmenopausal women with this popular route of administration.”

http://www.ncbi.nlm.nih.gov/pubmed/23652031

“…After application of topical progesterone, saliva and capillary blood levels are approximately 10-fold and 100-fold greater, respectively, than those seen in serum or whole blood. High capillary blood and saliva levels indicate high absorption and transport of progesterone to tissues. Reliance on serum levels of progesterone for monitoring topical dose could lead to underestimation of tissue levels and consequent overdose.”

http://www.ncbi.nlm.nih.gov/pubmed/15772572

“…Despite the low serum progesterone levels achieved with the creams, salivary progesterone levels are very high, indicating that progesterone levels in serum do not necessarily reflect those in tissues. The mechanism by which the serum progesterone levels remain low is not known. However, one explanation is that after absorption through the skin, the lipophilic ingredients of creams, including progesterone, may have a preference for saturating the fatty layer below the dermis.”

http://www.ncbi.nlm.nih.gov/pubmed/16120154

“…The results of this study demonstrate that topical 2% progesterone acts primarily in increasing elasticity and firmness in the skin of peri- and postmenopausal women. These effects in combination with good tolerability make progesterone a possible treatment agent for slowing down the ageing process of female skin after onset of the menopause.”

http://www.ncbi.nlm.nih.gov/pubmed/3988537

“…The causes and potential causes of androgenic alopecia in men and women are discussed. The scientific attempts at reversing this process are detailed including use of estrogen, thyroid, progesterone, and minoxidil. At present, the practical approach for the clinician is to ascertain in females that an androgen overproduction syndrome is not present. A therapeutic trial of topical progesterone at a 2%-5% concentration appears to be reasonable when the physician and patient appreciate the limitations of this approach.”

http://www.sciencedirect.com/science/ar … 369093017J“…Present osteoporosis management emphasizes prevention rather than cure since true reversal has proven unobtainable by conventional methods. With the hypothesis that progesterone is the missing ingredient for normal bone-building in women, transdermal progesterone supplementation (with or without estrogen) was tested in an office-based setting over a period of six years. Treatment resulted in progressive increase in bone mineral density (BMD) and, more importantly, definite clinical improvements evidenced by pain relief, height stabilization, increased physical activity, and fracture prevention. The benefits achieved were found to be independent of age. It is concluded that osteoporosis reversal is a clinical reality in a program that is safe, uncomplicated, and inexpensive.”